Abstract
The present study was attempted to enhance the production of naphthoquinones and phenolics by Fusarium solani PSC-R of Palk Bay origin, which exhibited potent antibacterial, antioxidant and dyeing activity. Maximum productivity of naphthoquinones and phenolics was achieved in potato infusion medium supplemented with 2% sucrose. Addition of nitrogen sources to the medium adversely affected the production of both naphthoquinones and phenolics. An initial pH of 5 and incubation at 31°C for six days at 140rpm was found to increase the yield (123.65mg/g of DW), concentration (867.33mg/l) and total naphthoquinones (602.8μM/g DW) by 7.58, 10.44 and 3.68-fold respectively. Similarly, the antioxidant and antibacterial activity associated with the phenolics of PSC-R increased by 1.5-fold in the optimized medium. The obtained results document the effective means of enhanced production of naphthoquinones and phenolics in the suspension culture of F. solani PSC-R at bioreactor level.
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