Production of Multiple Cell‐Laden Microtissue Spheroids with a Biomimetic Hepatic‐Lobule‐Like Structure (Adv. Mater. 36/2021)

Abstract

Biomedical Applications In article number 2102624, Songwan Jin and co-workers generate liver spheroids that resemble the in vivo structure of the lobules. The structural integrity is maintained for several days, engendering an increased performance of cellular function. This is achieved thanks to the combination of two cutting edge technologies: preset-extrusion 3D bioprinting and microfluidics. Moreover, structured microtissues once injected into animals show a better engraftment, bringing to light the importance of phenotypically relevant models not only for drug screening but also regenerative medicine.