Abstract
The solubility and bioavailability of pharmaceutical compounds are increased via size reduction. The conventional size reduction methods have some disadvantages. The pharmaceutical micronization with supercritical fluids (SCFs) techniques has been proposed. These methods overcome the disadvantages of conventional methods. Therefore, in this work, literature data analysis on the supercritical fluid micronization has been reviewed. The SC carbon dioxide is usually proposed. Micronization with supercritical fluids is classified based on the role of supercritical fluid in a process. Application of these methods for the pharmaceutical micronization has attracted interest in recent year because the micronized particles with narrow particle size distribution and no organic solvent are produced. These methods are rapid expansion of supercritical solutions (RESS) process, gas antisolvent (GAS) process, supercritical antisolvent (SAS) process, solution enhanced dispersion by supercritical (SEDS) process, aerosol solvent extraction system (ASES), supercritical fluid extraction of emulsions (SFEE), and particle from gas saturated solution (PGSS) process.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
