Abstract
Lutetium-177 (177Lu) radioisotope has been suggested for radioimmunotherapy application in nuclear medicine. Presently 177Lu has been mostly produced using neutron activation in nuclear reactors, whereas cyclotron-based production has not been well explored. In this paper, we theoretically propose cyclotron-based deuteron beams for 177Lu production. By Employing the TALYS 2017 codes, we calculated nuclear cross-sections and the End-of-Bombardment (EOB) yields of 176Yb(d,n) 177Lu reaction for direct production of 177Lu as well as 176Yb(d,p)177Yb→177Lu reaction for indirect production of 177Lu. The TALYS calculated cross-sections indicated that the threshold energy of both investigated nuclear reactions is 0 MeV; thus 177Lu could be produced at low deuteron energy bombardment, though significant amount of 177Lu radioactivity could only be generated for deuteron beams with energy greater than 6 MeV. The calculated EOB yields for 176Yb(d,n)177Lu reaction and 176Yb(d,p)177Yb reaction were 0.519 and 181.1 MBq/μAh respectively, which well agreed with previous experimental results published elsewhere. In conclusion, both nuclear reactions are possible for 177Lu production though the indirect method via 176Yb(d,p)177Yb→177Lu reaction would give much better EOB yield than that of direct method.
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