Abstract
Copper, magnesium and zinc deficient in vitro conditions were established in allogeneic mixed lymphocyte cultures (MLC) between splenocytes of C57B1/6 mice and x-irradiated splenocytes of Balb/cBy mice. Cellular levels of copper, magnesium and zinc were significantly lower in respective single element deficient media. The monocyte derived helper factor interleukin-1 (IL-1) and the T “helper” lymphocyte produced helper factor interleukin-2 (IL-2) were measured in these MLCs over six days. IL-1 levels in the culture supernatants were kinetically different from control levels in the copper deficient and zinc deficient MLCs, and were not measurable in the magnesium deficient MLCs. Only magnesium deficient MLC levels of IL-2 were different from control IL-2 levels and kinetics (no detectable IL-2 increases were measured with allogeneic stimulation). Immunological “help” is comparable to control levels in copper deficient and zinc deficient MLCs when “helper” T cells are present, whereas a marked decrease in “help” is found in magnesium deficient MLCs even with normal numbers of “helper” T lymphocytes.
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