Abstract

After several passages, bone marrow fibroblasts and stromal adherent layers of a long-living bone marrow culture derived from patients with chronic myeloleukemia cannot maintain hemopoiesis in a culture for a long time. Immunofluorescent microscopy and flow cytometry showed that fibroblasts after passing differ from stromal cells of a normal long-living bone marrow culture: they do not produce granulocytic colony-stimulating factor. Adherent layers of bone marrow culture derived from patients with chronic myeloleukemia contain a far lesser number of cells producing granulocytic colonystimulating factor than normal bone marrow cells.

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