Production of generalized Shwartzman reaction with group A streptococcal factors.

Abstract

SummaryA soluble factor from group A streptococcal skin lesions prepared American Dutch rabbits for the generalized Shwartzman reaction. The reaction can be provoked in rabbits prepared with this material not only with toxins from Gram-negative organisms but also by reduced filtrates of streptococcal cultures with a high streptolysin O content. The tissue changes associated with the reaction brought about with these materials include myocardial necrosis and cortical necrosis of the kidney. Although these reactions simulate those observed in the classical generalized Shwartzman reaction, points at difference are discussed. It was possible to immunize rabbits against the preparative activity of the soluble factor by repeated injections of the streptococcal skin lesion extract.