Abstract
This study focuses on the development possibilities of radiotracers used in PET in Senegal. This is a literature review that develops the production of 68-Gallium (68Ga[Ga]) via a medium to low energy cyclotron. It shows the possibility of producing 68Ga[Ga] with a simple production reaction using a target of 68Zn. This reaction provides high production yields, at the end of the bombardment (EOB), reaching up to 80 times the activity of a generator. PET imaging may offer better sensitivity and spatial resolution compared to SPECT which is currently used in Senegal. The acquisition of this type of medium to low energy accelerator in Senegal may constitute an important phase in the development of radiotracers with the objective of installing a PET imaging. However, solutions must be provided to minimize the presence of isotopic impurities.
Highlights
Gallium (Ga) is a chemical element belonging to the family of post-transition metals
This study focuses on the development possibilities of radiotracers used in PET in Senegal
PET imaging may offer better sensitivity and spatial resolution compared to SPECT which is currently used in Senegal
Summary
Gallium (Ga) is a chemical element belonging to the family of post-transition metals (group 13 of the periodic table of the elements). The use of the generator can be limited by its activity (typically 1.85 GBq of nominal activity when new); the minimum interval between elutions (typically 3 - 4 hours); the elution efficiency (~60% - 80%); and the potential for the parent radionuclide to be long-lived (68Ge[Ge]) crosses the column and ends up in the eluate (breakthrough) [5] [6] [7] [8] Taking these considerations into account, Jensen and Clark [9] have developed an innovative method to meet the growing demand for 68Ga[Ga]. Diarra (Figure 1), the reactions 65Cu (α, n) 68Ga and 68Zn (p, n) 68Ga are the best to produce 68Ga[Ga] from of a medium to low energy accelerator Among these two nuclear reactions, the irradiation of Zn by protons (68Zn[Zn] (p, n) 68Ga[Ga]) is the preferred one (the one we have chosen) according to several studies because it leads to a higher production yield with less impurities and uses protons, the simplest of all cyclotron projectiles [5] [11] [13] [15]
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