Abstract
Human amnion, trophoblast and umbilical vein endothelial cells synthesise an arachiodonic acid metabolite which is neither a lipoxygenase nor a cyclo-oxygenase product. It is sensitive to stimulants and inhibitors of the cytochrome-P450-dependent epoxygenase system and co-migrates on HPLC with 14, 15-epoxyeicosatrienoic acid (14, 15-EET), chich is an epoxygenase product. The function of 14, 15-EET in these reproductive tissues is unknown, but it may be involved in the maintenance of vascular function.
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