Abstract
Summary Porcine gastrin extract, pure porcine gastrin II, or saline was given by continuous intravenous injection to conscious, intact cats. The doses of gastrin selected were based on studies in other conscious cats with gastric fistulas. Two cats that received porcine gastrin extract for 12 hr in a dose that produced near maximal acid and pepsin secretion in cats with gastric fistulas had a normal appearance of the gastric and duodenal mucosa. In 7 of 8 cats that got the same dose of gastrin extract for 24 hr, erosions or ulcers occurred in the proximal duodenum, with gross bleeding in 4. Both of 2 cats that got the same dose of gastrin extract for 96 hr had duodenal ulcers, one with perforation, the other with obvious hemorrhage. One-fourth of the above dose of gastrin extract infused for 24 hr in 4 cats produced duodenal ulcers and erosions in all, but these were less severe than those produced by the larger dose. In all of 4 cats, porcine gastrin II infused for 24 hr in a dose that produced near maximal acid secretion in gastric fistula cats (2 μg per kg body wt per hr) produced severe duodenal ulcers with hemorrhage. A few of the cats with duodenal lesions had small erosions or ulcerations of the pyloric gland area or the oxyntic gland area of the stomach. In cats that received saline intravenously for 12, 24, or 96 hr the gastric and duodenal mucosa had a normal appearance.
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