Abstract
The nonenzymatic synthesis of 4-hydroxy-3, 5-diiodophenylpyruvic acid (DIHPPA) from diiodotyrosine is reported in this paper. The reaction was carried out in vitro in the presence of pyridoxal and metal ion. The yield of DIHPPA at 37°C for 2hrs. and at 100°C for 30 mins. were almost the same. Among metal ions used in the present study, Cu++ was found to be most effective. Co++ was also effective, while other ions, Al+++, Zn++, Mn++, Ni++, Fe++ and Fe+++ were only very slightly effective. The results obtained in this study suggest that the nonenzymatic reaction possibly takes place also in vivo.
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