Abstract
IT HAS been demonstrated that highly purified growth hormone preparations may produce temporary (idiohypophyseal) diabetes in cats (Cotes, Reed and Young, 1949) and in dogs (Campbell, Davidson, Snair and Lei, 1950). It has also been possible to produce permanent (metahypophyseal) diabetes by highly purified growth hormone in dogs previously used as test animals in assays of diabetogenic materials (Campbell, Davidson and Lei, 1950). In continuing these studies we have found that highly purified growth hormone greatly increased in dogs the erythrocyte sedimentation rate (ESR), decreased the volume per cent of red blood cells and appeared to increase the concentration of fibrin in the blood plasma. It is of considerable interest that these effects were most manifest when the diabetes induced by the growth hormone was also maximum.
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