Abstract
Bioactive compounds curcumin and resveratrol have been appointed to have potential for prevention and treatment of several diseases, replacing synthetic compounds with limited action. However, both present low aqueous solubility and bioavailability. Cocrystallization aims to modify physicochemical properties of active compounds by occurrence of intermolecular forces between them and possible modifications in the crystalline matrix. This research aimed to synthesize a curcumin-resveratrol cocrystal by the Cocrystallization with Supercritical Solvent (CSS) technique intending to improve the components solubility and dissolution rate. Characterization by Differential Scanning Calorimetry, X-Ray Powder Diffraction and Fourier Transform-Infrared Spectroscopy confirmed cocrystal formation. Comparing to raw components, cocrystal antioxidant activity was improved as well as dissolution rate. Curcumin and resveratrol solubility were improved 1.5 and 2 times, respectively. Behavioral tests in mice showed that curcumin-resveratrol antinociceptive/anti-inflammatory potency was increased probably due to alterations in its bioavailability, which gives the cocrystal good potential of use in the pharmaceutical industry.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
