Abstract
THE clonal growth of human bone marrow cells in vitro requires the presence of a stimulatory substance(s) designated colony-stimulating activity (CSA)1,2. Data available from various clinical and animal experiments suggest that CSA is, or is related to, a physiological controller of granulopoiesis3,4. Although the precise biological role of CSA is still uncertain, considerable insights into leukopoietic mechanisms have been gained from the study of interactions of CSA and haemopoietic cells in vitro. Two sources of CSA have been identified that stimulate colony formation from human bone marrow: certain foetal tissues and peripheral blood leucocytes3,4. The observation that CSA is produced by white cells led naturally to hypotheses concerning the feedback control of stem cells by mature leukocytes3,5.
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