Abstract
AbstractA new method to deliver carbon monoxide (CO) for medical applications is presented using a kHz‐driven helium plasma jet with a 1% CO2 admixture. Despite being known for its anti‐inflammatory, vasorelaxing, and anti‐apoptotic effects, a possible role of CO generated from plasma for the treatment of various diseases has so far been neglected. Here, we show that CO production of a plasma jet can be tuned from 100 to 2000 ppm. The number of CO molecules produced per pulse is in the range of 1 × 1012 to 1.5 × 1013. To assess the delivery of CO, mouse blood hemoglobin was used as a scavenger of CO and the consequent formation of carboxyhemoglobin was quantified. This study reveals for the first time that plasma can generate and deliver CO for therapeutic interventions.
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