Abstract
The purpose of this study is to evaluate the effect of the bioconversion products of Oenanthe javanica extract fermented by Lactiplantibacillus plantarum (OEFL) on relieving hangovers and improving liver function. In addition, the bioactive substance of the OEFL, which alleviates hangover and ethanol-induced liver damage, was identified and its bioactive property was verified through in vivo experiments. In major substances analysis using high-performance liquid chromatography, OEFL produced 9.5-fold higher p-coumaric acid than the O. Javanica extract (OE). In addition, considering that quinic acid, which is not present in the OE, was produced in the OEFL it was confirmed that chlorogenic acid was decomposed into quinic acid by bioconversion. In the in vivo experiment using Sprague-Dawley rats, the OEFL and p-coumaric acid diets reduced blood ethanol, acetaldehyde, GPT, and ALP concentrations, increasing blood albumin concentrations compared to ethanol-administered groups, demonstrating that OEFL and p-coumaric acid, the main substance in the OEFL, improved ethanol-induced liver damage. Furthermore, the OEFL and its main bioactive substance, p-coumaric acid, alleviated liver fibrosis by downregulating TGF-β, SMAD-2, SMAD-4, α-SMA, and upregulating MMP-1. Therefore, OEFL is expected to be used as a functional food or pharmaceutical material as it has been confirmed to effectively relieve hangovers, prevent liver damage, and delay liver fibrosis in ethanol-induced liver damages.
Highlights
While moderate drinking can provide positive effects, such as stress relief and cardiovascular disease reduction, excessive drinking leads to physical afflictions and psychological problems, such as cancer, liver disease, hangover, depression, dementia, etc. [1]
The purpose of this study is to evaluate the effect of the bioconversion products of Oenanthe javanica extract fermented by Lactiplantibacillus plantarum (OEFL) on relieving hangovers and improving liver function
A bioconversion of O. javanica extract using L. plantarum derived from kimchi was applied to improve the effect on a hangover relief and the recovery of ethanol-induced liver damage
Summary
While moderate drinking can provide positive effects, such as stress relief and cardiovascular disease reduction, excessive drinking leads to physical afflictions and psychological problems, such as cancer, liver disease, hangover, depression, dementia, etc. [1]. It is absorbed in the stomach and the small intestine, and metabolized by an enzyme, alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH), in the liver. 10–20% of the absorbed ethanol is metabolized by the microsomal ethanol oxidizing system (MEOS) and catalase (CAT). This metabolic pathway reportedly generates reactive oxygen species (ROS) that cause liver damage [8]. Since the oxidative stress engendered by the excessive ROS accelerates liver damage, reducing ethanol oxidation by the MEOS via the activation of ADH helps to protect the liver [9]. The liver diseases caused by ethanol-induced liver damage are fatty liver, hepatitis, and hepatocirrhosis [10]. Hepatocirrhosis treatment involves remedy such as steroid and pilin as liver function enhancers; their practical effects are ineffective and they have several side effects, including urtication, diarrhea, and enteritis and urgently increasing the need for an alternative remedy [12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
