Abstract
Centriole number is normally under tight control and is directly linked to ciliogenesis. In cells that use centrosomes as mitotic spindle poles, one pre-existing mother centriole is allowed to duplicate only one daughter centriole per cell cycle. In multiciliated cells, however, many centrioles are generated to serve as basal bodies of the cilia. Although deuterosomes were observed more than 40 years ago using electron microscopy and are believed to produce most of the basal bodies in a mother centriole-independent manner, the underlying molecular mechanisms have remained unknown until recently. From these findings arise more questions and a call for clarifications that will require multidisciplinary efforts.
Highlights
The centriole is a cylinder-shaped organelle that serves as the core of the centrosome or the basal body of the cilium[1,2,3,4,5]
Nascent centriole formation usually depends on pre-existing mother centrioles
In one cell cycle each mother centriole produces only one daughter centriole, that is directly adjacent (Figure 1). Such tight control ensures proper mitosis, since only two centrosomes are required to function as the spindle poles
Summary
The centriole is a cylinder-shaped organelle that serves as the core of the centrosome or the basal body of the cilium[1,2,3,4,5]. Mouse ependymal cells (MEPCs) displayed a similar centriole amplification process, but their deuterosomes are usually much larger in size and smaller in number (Figure 2C). The beauty of such a DD pathway is obvious: cycling cells only need to turn off the DD pathway by shutting down Deup[1] expression to avoid the production of extra centrioles. Based mainly on studies in MEPCs, a model is proposed in which an unknown mechanism recruits Deup[1], Ccdc[78], and other cradle proteins to a site in the cradle of the young mother centriole to initiate the assembly of both the deuterosome and the daughter centrioles. A comprehensive knowledge of strategies for centriole amplification throughout metazoan evolution will require an understanding of the mechanisms for multiciliogenesis in the invertebrate
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