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Abstract
Cloned cell lines of guinea pig tumor induced by the Snyder-Theilen strain of feline sarcoma virus with feline leukemia virus subgroup C as helper, ST-FeSV (FeLV-C), have been established. The cell line releases high titers of ST-FeSV (FeLV-C) (10 3−10 4 FFU/0.2 ml) and 1 log excess of FeLV-C. In vivo studies of one of the cell lines, GPTC C1 1, showed that as little as 100 cells could induce tumors in weanling guinea pigs. The tumors progressively grew and eventually killed the animals within 23 days. Sera from guinea pigs carrying tumors contain antibodies to FeLV group-specific antigen, FeLV-C virus envelope antigen, and feline oncovirus-associated cell membrane antigen (FOCMA). The three groups of antibodies seem to be distinct as demonstrated in the absorption tests with appropriate antigens.
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