Abstract
The frequency of gastric acid breakthrough and accompanying esophageal reflux in patients with GERD is not known. Aim: To determine the prevalence of noctumal gastric acid breakthrough and associated distal esophageal reflux in patients with GERD who are treated with PPI. Methods: Records from the esophageal lab from 1989-1997 were reviewed to determine the number of patients having pH metry while on PPI BID. Fifteen patients with Barrett's (13 males; mean age 53 yr, range 29-73 yr) and 60 patients with GERD but no Barrett's (25 males; mean age 47 yr, range 20-81 yr) were studied by ambulatory dual electrode (esophageal and gastric) pH testing on PPI BID. Supine gastric acid breakthrough defined as pH 1 hour in supine position, and esophageal reflux defined as > 0% time supine distal esophageal pH < 4 during breakthrough period. Results: The prevalence of nocturnal supine gastric acid breakthrough and accompanying esophageal acid reflux is shown below.
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