Abstract
All isolates of Phoma exigua Desm. var. exigua and about 60% of isolates of P. exigua Desm. var. foveata (Foister) Boerema produce on 2% malt agar an antibiotic principle (Antibiotic ‘E’) which, in vitro, is antagonistic to a number of Gram-positive and Gram-negative bacteria and two fungal species. It is bactericidal and fungicidal. The compound was partially purified by paper chromatography and the active principle is considered to be a phenolic derivative. It is diffusible, water-soluble, heat-stable and has reducing properties. Isolates of var. foveata which do not produce Antibiotic ‘E’ differ consistently in cultural characteristics from those which do by the production of higher concentrations of anthraquinone pigments and more abundant aerial hyphae.
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