Abstract
ACID mucopolysaccharides characteristic of connective tissue ground-substance are produced in tissue culture by fibroblasts from a variety of tissues of mesenchymal derivation1–4. It would appear that in the conditions of growth in tissue culture the spectrum of acid mucopolysaccharides typical of a given tissue5 is not reproduced. Rather the results suggest that the cultured cells, whatever their tissue of origin, revert to a similar pattern with respect to production of acid mucopolysaccharides in that all secrete into the medium a major fraction of hyaluronic acid and a smaller component of sulphomucopolysaccharide, presumably chondroitin sulphate C 2,3. Moreover, the present experiments show that production of acid mucopolysaccharides by ‘stock’ strains of fibroblasts may continue in tissue culture for long periods of time, up to years.
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