Abstract
A new cyclic depsipeptide (1) has been isolated from culture broth of Staphylococcus sp. (No. P-100826-4-6) derived from Corallina officinalis L., together with the known compounds indol-3-carboxylic acid (2), 1,5-dideoxy-3-C-methyl arabinitol (3), thymine (4), uracil (5), cyclo (L-pro-L-omet) (6) and macrolactin B (7). The structure of (1) was established to be cyclo (2α, 3-diaminopropoinc acid-L-Asn-3-β-hydroxy-5-methyl-tetradecanoic acid-L-Leu1-L-Asp-L-Val-L-Leu2-L-Leu3) by extensive spectroscopic techniques including 1H NMR, 13C NMR, 1H‒1H COSY, HMBC, HSQC, NOESY, and HRFABMS. The antimicrobial activities of compounds 1–7 were evaluated. Compounds 1–5, and 7 showed moderate antimicrobial activity while compound 6 exhibited a potent antimicrobial and antifungal activities.
Highlights
Bioprospecting studies of endophytic microorganisms play a principal part in the discovery of lead compounds for the improvement of drugs for the management of humanity’s diseases [1,2,3]
The antimicrobial activities (Table 3) of compounds 1–7 were examined for their growth inhibition of 6 microorganisms including Gram-negative, Gram-positive bacteria and fungi using paper disk method withantimicrobial replication
The antimicrobial activities (Table 3) of compounds 1–7 were examined for their growth inhibition of 6 microorganisms including Gram-negative, Gram-positive bacteria and fungi using paper disk method with replication (n = 2)
Summary
Bioprospecting studies of endophytic microorganisms play a principal part in the discovery of lead compounds for the improvement of drugs for the management of humanity’s diseases [1,2,3]. Peptides, which were derived from different organisms including marine microbes, represent an important chemical class with diverse structures. The biological activity of marine-derived peptides has been shown organisms including marine microbes, represent an important chemical class with diverse structures and to significant depend onbiological the composition aminoofacids, their structural properties, well as activities.and. These substances are actively on the composition and sequencebacteria of amino[11,12].
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