Abstract
MA/MyJ mice express a natural antibody to the highly oncogenic polyoma virus. C57BR/cdJ mice lack this antibody but mount an adaptive T-cell response to the virus. Analysis of F2 progeny of a cross between these strains reveals a pattern of inheritance of expression of the natural antibody involving two genes in an epistatic relationship.
Highlights
Two forms of resistance in inbred strains of mice to the oncogenic effects of polyoma virus emerged in the course of studies of the effects of ionizing radiation on development of virus-induced tumors (Carroll et al 1999)
A hemagglutination-inhibition (HA-I) assay (Carroll et al 2007) based on serial twofold dilutions of sera reveals the presence of this natural antibody
We report the use of genome-wide single nucleotide polymorphism (SNP) analysis of the F2 progeny of a cross between MA and BR to identify the genetic loci controlling production of the natural antibody
Summary
Two forms of resistance in inbred strains of mice to the oncogenic effects of polyoma virus emerged in the course of studies of the effects of ionizing radiation on development of virus-induced tumors (Carroll et al 1999). Sera from normal MA mice show high levels of a natural antibody capable of neutralizing the virus. The neutralizing activity of sera from uninfected MA is roughly an order of magnitude lower than that found in experimentally or naturally infected mice (Carroll et al 2007).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
