Abstract
Production and secretion of 5α reduced metabolites of testosterone by male reproductive organs have been discussed. In spite of the fact that such organs appear to need androgens for proper biological function, secretion of dihydrotestosterone takes place by the infused testis, prostate and epididymis of the dog. Regulation of this type secretion is currently unknown. Seminiferous tubules as well as Leydig cells from testes of mature rats convert testosterone to dihydrotestosterone and progesterone is a potent inhibitor for this biotransformation. Data from experiments show that testicular metabolites of dihydrotestosterone have androgenic effects.
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