Abstract
Zirconium-89 (89Zr) is an interesting immuno-PET imaging agent due to its favorable physical characteristics of 78.4 h half-life and a relatively low positron energy of 0.9 MeV. Radiochemical separation of 89Zr from irradiated yttrium target matrix has been achieved by different separation methodologies like anion-exchange chromatography, cation-exchange chromatography and size exclusion chromatography (Sephadex G-25 resin). A novel and simple method based on size exclusion chromatography (Sephadex G-25) for radiochemical separation of 89Zr with no harmful substances has been explored. The experimental yield of 89Zr from natural yttrium target was found to be 27 MBq/μAh using 12 MeV proton. The radiochemical separation yield, radionuclidic purity and chemical purity of 89Zr using an anion exchanger, Dowex-1 resin/2 M HCl column system and Sephadex G-25 resin column was found to be high enough.
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