Abstract
A new production method of no-carrier-added 64Cu was tested using a new target prepared by electroplating of Ni on a silver layer (thickness 35 μm) previously electroplated on a pure copper target support. This method meets cost effective production and quality of the produced 64Cu criteria. The quality of the electroplated layers has been tested under the bombardment by more than 200 μA of proton beam using water cooled target system. A separation and purification setup was elaborated to produce high quantity and high specific activity of 64CuCl2 suitable for labeling different ligands in order to be used in therapy and diagnosis. A semi-automated target dissolution and separation system has been developed and achieved for 64Cu production. The separation chemistry is based on a chromatographic column system.
Highlights
The radionuclide 64Cu (T1/2 = 12.7 h) emits β− 39% and βch+ a1r7a.c4te%ris(tEic s mmaxa ke65it6 KeV ; usefulEf o rmabxo=th57h3igKheVre)s.oTluhteiosnePET imaging and targeted endoradiotherapy
A separation and purification setup was elaborated to produce high quantity and high specific activity of 64CuCl2 suitable for labeling different ligands in order to be used in therapy and diagnosis
We would like to prove that high quality and quantity of 64Cu can be produced using a new target prepared by the electroplating of Ni on silver layer previously electroplated on a pure copper target support
Summary
Its electron capture decay associated with Auger emission gives more efficient cell killing when this radioisotope is deposited in the cell [1]. Another advantage of this important radionuclide is the stability of its complexes with bifunctional chelators consisting of the metal complex ligand and the functional group for attachment to the targeting molecule [2]. Due to the fact that target support (gold disk) can be used for one time and irradiation beam intensity used for this target support is very low resulting low quantity of the produced 64Cu radioactivity. A quality control of the produced radioactive copper is carried out
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