Abstract
The production of 89Zr via the (p, n) reaction on 89Y using 11 MeV protons was studied. Thick target yields at saturation were measured to be 100 ± 10 mCi/ μA while thin target (57 mg/cm 2; 11 MeV > E p > 10 MeV) yields were found to be 43 ± 4 mCi/ μA. 89Zr was separated from the Y target by extraction into 0.03 M dibutyl phosphate in dibutyl ether. Back-extraction into 4 M HF followed by anion exchange column chromatographic purification results in high purity no carrier added 89Zr with radiochemical yield of 84% ± 4%. Yttrium contamination is estimated to be less than the picogram level. 89Zr-linked to proteins via DTPA may be useful as a PET antibody label.
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Schedule a callMore From: International Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes
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