Production and Formulation of Postbiotics for Treatment of Acne Vulgaris

Abstract

In dermatology, the development and formulation of postbiotics have gained significance for skincare treatment. Postbiotics, deceased organisms promoting host health, exhibit potential in modifying skin microbiota, enhancing the skin barrier, and reducing inflammation. Present research focuses on postbiotic production and their application in treating acne vulgaris. Although postbiotic use in skincare is nascent, acne, a chronic inflammatory condition, stems from factors like increased androgen-induced sebum production, altered keratinization, inflammation, and Propionibacterium acnes colonization. Nonetheless, implementing postbiotics faces challenges like nomenclature, regulatory issues, and safety concerns. Further exploration is essential to establish global standards and regulations, enabling the creation of safer, more sustainable postbiotic products. Addressing these aspects could revolutionize skincare, employing postbiotics responsibly and effectively, particularly for conditions like acne vulgaris. Achieving this requires consistent manufacturing, extensive clinical trials, and continuous research to comprehend mechanisms of action and validate the efficacy and safety of postbiotic-based skincare.