Abstract
AbstractIn this study, we reported that the reactivity of 1,3-dicarbonyls with sodium hypochlorite pentahydrate (NaOCl·5H2O) as an easy-to-handle oxidant, alters greatly depending on the pH value. The reaction of NaOCl·5H2O under weakly basic conditions (pH 12) gives the corresponding carboxylic acids in up to 97% yield. Upon addition of AcOH (pH 5), chlorination of active methylene sites proceeds efficiently to afford dichlorinated products in high yields.
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