Producing and characterizing PCL/PA6 three dimensional nanofibrous scaffolds for tendons and ligaments regeneration

Abstract

Event Abstract Back to Event Producing and characterizing PCL/PA6 three dimensional nanofibrous scaffolds for tendons and ligaments regeneration Chiara Rinoldi1, Ewa Kijeńska1 and Wojciech Swieszkowski1 1 Warsaw University of Technology, Faculty of Materials Science and Engineering, Poland Regenerative medicine is an interdisciplinary field that applies the principles of engineering and biology to develop biological substitutes to repair, replace or improve the cell functions, tissues or organs, damaged by congenital defects, trauma or aging. Three-dimensional scaffold systems promote cell growth and proliferation, providing a physiological and mechanical environment suitable for cell culture. Scaffold materials should mimic the native extracellular matrix (ECM) and its complex features, enhance fluid transport within the matrix (O2 and nutrients) and favor the disposal of metabolic wastes. The aim of this work is to design and fabricate 3D biodegradable electrospun nanofibrous structures, which can provide adequate environment and bio-signals for cells. Polycaprolactone (PCL) and Polyamide 6 (PA6) were selected to produce the scaffold, due to their biocompatibility, slow degradability, non toxicity and high mechanical properties. The polymers blends were dissolved in an innovative dissolvent system composed by Acetic acid and Formic acid, which are less toxic than the common organic solvents used for PCL dissolution. The overall scaffold architecture, its structure at micro and nanoscale, its chemical composition and mechanical properties were optimized. The control of the degradation kinetics and the homogeneous cell distribution was investigate to guarantee a successful therapy. The results of this study suggest that the PCL/PA6 nanofibrous scaffold might be interesting alternative for tendons and ligaments regeneration. This study was supported by the National Center for Research and Development (STRATEGMED1/233224/10/NCBR/2014, project START). Keywords: nanofiber, Tissue Regeneration, 3D scaffold, Biodegradable material Conference: 10th World Biomaterials Congress, Montréal, Canada, 17 May - 22 May, 2016. Presentation Type: Poster Topic: Regenerative medicine: biomaterials for control of tissue induction Citation: Rinoldi C, Kijeńska E and Swieszkowski W (2016). Producing and characterizing PCL/PA6 three dimensional nanofibrous scaffolds for tendons and ligaments regeneration. Front. Bioeng. Biotechnol. Conference Abstract: 10th World Biomaterials Congress. doi: 10.3389/conf.FBIOE.2016.01.02858 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Mar 2016; Published Online: 30 Mar 2016. Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Chiara Rinoldi Ewa Kijeńska Wojciech Swieszkowski Google Chiara Rinoldi Ewa Kijeńska Wojciech Swieszkowski Google Scholar Chiara Rinoldi Ewa Kijeńska Wojciech Swieszkowski PubMed Chiara Rinoldi Ewa Kijeńska Wojciech Swieszkowski Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.