Produce of Selenium Nanoparticles by Pulsed Laser Ablation for Anticancer Treatments

Abstract

The most serious public health problems now involve antibiotic resistance and cancer that kills more than 15 million people per year which indicates that the existing antibiotics and chemotherapy are not as active as before. This paper provides nanotechnology as a possible answer. However, typical physicochemical nanomaterials production processes, frequently requiring the use of harmful catalysts, have environmental or social implications. This paper covers how to use the innovative liquid-pulsed laser ablation (LP-PLA) process to manufacture selenium nanoparticles (SeNPs). After the first set of radiation at 500[Formula: see text]mJ laser energy and 100 pulses, a second set was employed to decrease the size to less than 100[Formula: see text]nm with the same condition. Therefore, two main groups of 80 and 10[Formula: see text]nm had colloidal solutions for spherical SeNPs. The particles were also more stable following the second round of irradiation. Furthermore, when SeNPs were grown with human dermal fibroblast cells at doses up to 1[Formula: see text]ppm, they had a mild cytotoxic impact. The potential of utilizing totally naked SeNPs produced using the novel LP-PLA procedure as a novel and efficient way of producing nanoparticles for biomedical applications is presented in this paper.