Abstract
Malaria disease is endemic in least developed countries like Ethiopia. This disease is caused by protozoa of the genus Plasmodium infection that is easily recognizable from the symptoms of prolonged fever. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The plant Artemisia annua is the sole source of artemisinin in the industry. The main objective of the project was to provide a simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from the plant Artemisia annua Furthermore, this work was focus on the mass and energy balance calculation of the antibiotic Artemisia annua in the large scale industry.
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