Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach

S Mazzitelli,L Capretto,X.L Zhang,L Penolazzi,E Lambertini,R Piva,C Nastruzzi

doi:10.1016/j.jconrel.2010.07.014

Process optimization for the production of alginate microparticles containing wjmscs by a design of experiments (doe) approach

S Mazzitelli, L Capretto + Show 5 more

https://doi.org/10.1016/j.jconrel.2010.07.014

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Journal: Journal of Controlled Release	Publication Date: Nov 1, 2010
Citations: 3

Affiliation: University of Ferrara, University of Southampton

#Wharton's Jelly Mesenchymal Stem Cells #Wharton's Jelly Mesenchymal Stem + Show 8 more

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Abstract

The paper describes (a) the isolation and characterization of Wharton's Jelly Mesenchymal Stem cells (WJMSCs), (b) the encapsulation of WJMSCs in alginate microbeads by an encapsulation device based on a vibrating-nozzle, (c) the optimization of the procedure for the encapsulation of WJMSCs by a Design of Experiment (DoE) approach, and (d) the evaluation of viability, proliferation and osteoblastic differentiation of the encapsulated WJMSCs.

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