Abstract
Research on microneedles has been increasing rapidly as to overcome the drawbacks of conventional needle which can results in painful during injection, tissue damage and skin infection at the injected site. This paper presents characterization process of wet isotropic etch for solid microneedles array development. This approach utilizes HNA etchant to build the outer shape of solid microneedles. Works has been carried out to investigate the isotropic etching behavior of HNA in different temperature ranging from 20 to 50 degrees, various agitation rate ranging from 0 rpm to 450 rpm and on the various window size ranging from 100 μm to 500 μm. Characterization on those factor, determine the effect of vertical and lateral etch rate variations, surface quality and the geometry obtained. The experimental responses of vertical etch rate, lateral etch rate and high aspect ratio reported. The obtained etching properties will be applied to develop recipes to fabricate outer shape of solid microneedles’ tip.
Highlights
Delivering medicine through skin is seen as a desirable alternative instead of taking it orally
We will study the behavior of silicon in HNA composition (20%wt HF:70%wt HNO3:10% wtCH3COOH) in various temperature ranging from 20 to 50 degrees, in various agitation rate ranging from 0 rpm to 450 rpm and on the various window size ranging from 100 μm to 500 μm
HNA solution that heated above 35 oC will produce a structure with high aspect ratio less than 1 as the lateral etch rate is higher than the vertical etch rate
Summary
Delivering medicine through skin is seen as a desirable alternative instead of taking it orally. Transdermal drug delivery which is a form of controlled delivery promises a convenient administration of drugs over extended period of time, reducing the side effects and provides a constant dosage. This alternative approach is utilizing solid microneedles array which are effective in forming micropores; large enough for molecules to enter in the outer skin layer. McAllister et al [2] demonstrated in vitro experiments showed that inserting microneedles into a skin can increase its permeability for small drugs, large
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