Procena kardiovaskularnih faktora rizika u bolesnica sa sindromom policističnih ovarijuma

Abstract

Polycystic ovary syndrome (PCOS) is the most frequent reproductive disorder in women. PCOS is considered a metabolic disorder closely related to obesity, insulin resistance, hyperinsulinism and unfavourable lipid profile, and all together increases the risk of cardiovascular diseases. The objective of the study was to estimate the concentration of individual lipid fractions in obese PCOS patients as well as to examine the possible connection of changes in lipid fractions regarding the age of the patients. There were 59 obese patients with PCOS examined, who were divided into two groups: < 20 years (group A, n=22) and > 20 years (group B, n=37). The results of these groups were compared with the corresponding from the control groups (groups C and D). Basal values of cholesterol, HDL, LDL, triglycerides, oxidated LDL, Apo AI, Apo AII, Apo V, Apo E and atherogenic indices Apo B/Apo AI and LDL/HDL were analysed. A statistically significant difference between the groups A and V for the total cholesterol (4,20 vs. 5,02 mmol/L), LDL-cholesterol (2,79 vs. 3,42 mmol/L), triglycerides (1,27 vs. 1,50 mmol/L), oxidatedLDL (56,35 vs. 65,17 U/L), Apo V (0,87 vs. 1,03 g/L), Apo B / Apo AI (0,55 vs. 0,68) and LDL / HDL (2,37 vs. 3,06) was determined. It was conformed that in the obese patients with PCOS there was significantly higher level of almost all analysed lipid fractions and atherogenic indices with extremely high oxidation of LDL cholesterol. The PCOS patients have significantly higher atherogenic potential with ageing.