Abstract
The proceedings of the 3rd Annual Deep Brain Stimulation Think Tank summarize the most contemporary clinical, electrophysiological, imaging, and computational work on DBS for the treatment of neurological and neuropsychiatric disease. Significant innovations of the past year are emphasized. The Think Tank's contributors represent a unique multidisciplinary ensemble of expert neurologists, neurosurgeons, neuropsychologists, psychiatrists, scientists, engineers, and members of industry. Presentations and discussions covered a broad range of topics, including policy and advocacy considerations for the future of DBS, connectomic approaches to DBS targeting, developments in electrophysiology and related strides toward responsive DBS systems, and recent developments in sensor and device technologies.
Highlights
The Third Annual Deep Brain Stimulation (DBS) Think Tank convened at the University of Florida’s Research and Academic Center in Orlando, FL, on March 18-20, 2015
One imaging technique well suited to visualizing brain networks is resting state functional connectivity magnetic resonance imaging (Fox and Raichle, 2007). This technique has already been demonstrated to (1) identify thalamic DBS targets based on connectivity to brain regions implicated in tremor (Anderson et al, 2011), (2) link invasive and non-invasive brain stimulation sites across 14 different neurological and psychiatric diseases (Fox et al, 2014), and (3) be safely applied in patients implanted with DBS electrodes using special low-energy MRI sequences (Kahan et al, 2014)
These findings suggest that both the beta oscillations and broadband gamma activity might be relevant to psychiatric symptoms, and that the excessive synchronization observed in cortical-basal ganglia motor networks might occur in cortical-basal ganglia networks involved in emotion and cognition
Summary
The Third Annual Deep Brain Stimulation (DBS) Think Tank convened at the University of Florida’s Research and Academic Center in Orlando, FL, on March 18-20, 2015. The meeting was conducted in a “think tank” style; speakers presented analyses of critical issues to foster dialog in subsequent discussions The nature of this think tank format implies that this is not an evidence-based overview of developments in DBS; rather, it is a report of ongoing developments that have been advancing this dynamic field and discussion of obstacles hindering further advancement and potential solutions. This summary includes key points of both the presentations and the follow-up discussions
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