Abstract
DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging deep brain stimulation (DBS) technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury.
Highlights
The deep brain stimulation (DBS) Think Tank IX presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry
How do people experience the application of DBS in the ongoing course of their lives within their own social groups? How do people assess DBS’s value for themselves, in terms of their healthcare needs and their mutable self-conceptions and values? How has the application of DBS for members of society been evaluated for responsible innovation, genuine social need and justice? How does a culture generally assess DBS’s impacts on people’s lives, according to customary values, cherished ideals, and established laws? In general, a brain cannot determine the self, since self-conceptions are tied to social capabilities
This year, the DBS Think Tank IX advances focused on cuttingedge technologies and the use of novel methodologies for tracking and suppression of symptoms
Summary
The DBS Think Tank IX presenters pooled data and determined that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. The proposed aDBS paradigm resulted in clinical efficacy and tremor suppression comparable with cDBS within a range of common actions (cup reaching, proximal and distal posture, water pouring, and writing), with a considerable reduction of stimulation delivered, showing the potential for integrating DBS therapy with the patient behavior and for potentially addressing pitfalls of cDBS for ET, such as DBS-induced side effects and premature device replacements. ECAP-controlled closed-loop spinal cord stimulation provided statistically superior pain relief and greater improvement in all other measures compared with the OL group at 3, 6, 12, and 24 months This significant improvement in clinical outcomes was consistent with the CL group being able to better maintain the targeted spinal cord activation level as measured by the stability in the ECAP amplitudes. The data presented were derived from survey respondents with clinical, scientific, engineering, and commercial expertise and had academic, industrial, government, and non-profit professional backgrounds
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