Proceedings of the International Cancer Imaging Society (ICIS) 16th Annual Teaching Course

Dow‐Mu Koh ,Bernhard Gebauer,F Constantinidis,S Viswanathan,R Pozzi Mucelli,Aslam Sohaib,Arnoldo Piccardo,Kate Downey,Philippe Moerman,Frederik De Keyzer,Jurgen J Fütterer,Ignace Vergote,Ann D King,Theresa C Mcloud,Markus Raderer,Nicholas Van As,Michel Koole,Ashish P Wasnik,Ravi K Kaza,L Múgica Álvarez,H Dobson,Stefan Diederich,G González Zapico,Harriet C Thoeny,Matthias Eiber,Giovanni Morana,Vincent Vandecaveye,Elleke Dresen,Alexander J Towbin,Jay P Heiken,Andrea Rockall,S Ibáñez Alonso,Jeong Min Lee,Andrea Rossi,E Goldstraw,Alexander Haug,M D Pascuzzi,Hersh Chandarana,Kirk A Frey,Marius E Mayerhoefer,E Eyheremnedy,Maria Luisa Garrè,Isaac R Francis,L Potti,Mahmoud M Al-Hawary,Sileny Han,R Rueben,T Gillanders,Hebert Alberto Vargas,E Crowe,J Lee,E P Eyheremendy,M Reimold,I Tavera Bahillo,F Saguier,Abdullah Saad Al-Adhami ,Al Muller ,Alison Yong ,Andrew Evans ,Andrew Odhiambo ,Andrew Stephens ,André D’hoore ,André Jacques ,Andrés Zanfardini ,Anju Sahdev ,Ankur Seth ,Anna Beattie ,Anne Smets ,Anthony Maraveyas ,Archana Seth ,Ashok Adams ,B.k Choudhury ,Badiuddin Nazir ,Benjamin Taylor ,Bernard L Kaye ,Binu Mathew ,Brigitte Gückel ,C.l Chaw ,Carlos Rodríguez‐Galindo ,Christian Herold ,Christian La Fougère ,Christina Pfannenberg ,Christophe Stove ,Chun Hai Tan ,Chuong Ho ,Claire Johnson ,Colin A Purdie ,Cristina Carrera ,David Simons ,Dimitrios Christodoulou ,Dona Bowers ,Douglas J Quint ,Eitan Lovat ,Elena Tagliabue ,Ernesto Jáuregui ,Faraz Arfeen ,Faye S Silverstein ,Frédéric Amant ,G Joseph ,Gary Cook ,Ged Avery ,George Bozas ,Giuseppe Petralia ,Golap Gunjan Barman ,Gregory P Kalemkerian ,Gurdip Kaur Azad ,Hp Schlemmer ,Jaclyn Goodfellow ,James Boon-Kheng Khoo ,Janine Mansi ,Jeyanthi John ,Kalpa Sharma ,Karda Cavanagh ,Karen Partington ,Katie Dutton ,Khin Yadanar Thein ,Kimberly G Harkins ,Konstantin Nikolaou ,L W Childs ,Lei Dang ,Leslie E Quint ,Lisa Alarcon ,Mahdi Nazar ,Maja Vanek ,Manil Subesinghe ,Marc Carlson ,Marianne J D’onofrio ,Mark Harries ,Markus Wirtz ,Matthew C Hall ,Matthew R Digby ,Michael Sproule ,Monika Uhrig ,Musib Siddique ,Nazleen Muhammad Gowdh ,Neerja Gupta ,Nicholas Griffin ,Nick Taylor ,Nir Harish ,Norbert Schwenzer ,Olivia Francies ,P Ramos ,Paola Pricolo ,Paul Summers ,Peter Martus ,Rajesh Burgul ,Ramces Francisco ,Raphaëla C Dresen ,Raymond Trevor Bradley ,Riccardo De Robertis ,Rishindra M Reddy ,Robin E Ferner ,Ronald E Wheeler ,Rubin Soomal ,Sarah Vinnicombe ,Shaheel Bhuva ,Shelley A Waugh ,Shikha Joshua ,Silke Schüle ,Simina Luca ,Sofia Gourtsoyianni ,Sofie De Vuysere ,Stacey Sheridan ,Stanley M Smith ,Stefano Crosara ,Steven B Kaufmann ,Steven M Leber ,Stuart Murdoch ,Subodh Seth ,Sue Jenkins ,Tharshini Jeyakumar ,Thierry A G M Huisman ,Thomas R Campion ,Timothy Musila Mutala ,Tze Hern Teo ,Valentina Ciaravino ,Vicky Goh ,Victoria Warbey ,Véronique Blanchet ,W.j.g Oyen ,Igor Fagner Vieira ,Sue C Kaste ,S Alessi,P Jennings,E Van Cutsem,A Wolthuis,F Troncoso,A Thompson,Derek Roebuck,Nick Reed,Y L Thian,S E De Luca,K Bujarbarua,Mirko D’Onofrio,Eric Lau

doi:10.1186/s40644-016-0079-z

Abstract

Proceedings of the International Cancer Imaging Society (ICIS) 16th Annual Teaching Course

Highlights

The Deauville Score (DS) is a standardised five-point scale developed to assess treatment response in lymphoma
Following initial work confirming high concordance of the reporting criteria between reporters, with respect to use in clinical trials [1], the scoring system was adopted as the preferred method for reporting of response assessment in lymphoma at the First International Workshop on Positron emission tomography (PET) in Lymphoma in Deauville, France, in 2009 [2]
Since the DS has been increasingly used in clinical practice and in national and international trials as a simple, quick and reproducible method to assess response to treatment in lymphoma, with good interobserver agreement reported in several studies [5, 6, 7]

Summary

Introduction

The Deauville Score (DS) ( referred to as the Deauville criteria) is a standardised five-point scale developed to assess treatment response in lymphoma. An alternative for PSMA-based imaging agents for PET/CT is the synthetic L-leucine analogue fluciclovine (FACBC), which was very recently approved by the FDA It depicts functional activity of two different transmembrane amino acid transporters (ASCT2 and LAT1). The distribution of the tracer in the body is favourable (negligible uptake in the kidneys, no activity in the urinary tract) and the detection rate of tumours seems to compare favourably to choline PET/CT when PSA levels are low. Another option is F-18 labelled 5αdihydrotestosterone (FDHT), directly targeting the intracellular androgen receptor. Defining the position of all the available options for molecular imaging in the diagnostic algorithms of the various stages of disease and convert this into guidelines are upcoming challenges

Objectives

Methods

Results

Conclusion