Abstract
Proceedings of the 23rd Paediatric Rheumatology European Society Congress: part two
Highlights
Systemic juvenile arthritis - a rare chronic disease
We searched for gene mutations that is responsible for autoinflammatory disease in Systemic juvenile idiopathic arthritis (SJIA) patients who had persistent clinical symptoms or flare even under treatment with glucocorticoid, disease-modifying antirheumatic drugs (DMARDS), and IL-6 receptor inhibitor
Increased mRNA expression for CP was seen in response to IFN-α (0.593 ± 0.227; p = 0.05), a cytokine known to be increased in Juvenile-onset Systemic Lupus Erythematosus (JSLE), compared to healthy controls (0.019 ± 0.02); no significant changes in mRNA expression were noted of the other biomarkers were present following stimulation with the other cytokines
Summary
Systemic juvenile arthritis - a rare chronic disease. Register it's an important tool to monitor the effectiveness and safety of GIBP. Musculoskeletal and rheumatic manifestations of cystic fibrosis (CF) are well described, including cystic fibrosis-related arthropathy (CFA), hypertrophic pulmonary osteoarthropathy (HPOA), antibiotic associated arthralgia ( ciprofloxacin-related arthropathy), osteopaenia and osteoporosis, as well as coincidental incidence of rheumatic conditions such as juvenile idiopathic arthritis and biomechanical issues such as postural abnormalities.[1] The prevalence of musculoskeletal symptoms in CF patients increases with age and occurs more frequently in adults, children may suffer from musculoskeletal complications of CF.[1] Objectives: To describe the cohort of children with cystic fibrosis referred to the rheumatology clinic at our tertiary paediatric centre with musculoskeletal symptoms over an eleven-year period.
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