Proceedings: Clinical value of predictive tests for advanced breast cancer.

E Engelsman

doi:10.1038/bjc.1974.178

Abstract

With different endocrine measures remissions may be brought about in 30% of cases of advanced breast cancer. Remissions seen after ablative procedures are best. However, average survival of the 70% of nonresponders is short, especially if the therapy is adrenalectomy. Several techniques to predict response have been investigated. There is correlation between uptake of tritiated estradiol by the tumor tissue in vitro and the response to endocrinetherapy, but this test is not for routine use. Correlation between the presence of receptors in breast cancer tissue and a favorable response to adrenalectomy or other endocrine treatments has been demonstrated. As a first treatment nafoxidine can produce remissions but it prevents effectiveness of a second therapy with estrogens. A successful first therapy with estrogens may be followed by a second remission with nafoxidine. In 3 patients estrogen receptors have been negative in new biopsy material after hormone treatment although negative results had been reported in previous tests. In these cases subjective remissions had been obtained with estrogens or androgens.

Highlights

Receptors in breast cancer metastases was Endocrine therapy is known to be of facilitated by the circumstances that our value to some patients with advanced breast staff work together as a team and that all the cancer
The patients who experience re- services needed are found under the same mission after endocrine therapy are said to roof: surgery, internal medicine, pathology have hormone dependent tumours
The advanced survival of patients with hormone dependent breast cancer cases were usually treated tumours is better than of those with non- according to clinical trial protocols of the responsive tumours

Summary

Introduction

Receptors in breast cancer metastases was Endocrine therapy is known to be of facilitated by the circumstances that our value to some patients with advanced breast staff work together as a team and that all the cancer. With different endocrine EORTC Breast Cancer Group; the receptor measures, remissions can be brought about in determinations were done initially by a about 30% of the patients.

Results

Conclusion