Proceedings: Accelerated induction of cerebrovascular lesions in young stroke-prone and -resistant SHR after simultaneous bilateral carotid ligation.

Abstract

SHR were clearly vulnerable to hypoxia induced by simultaneous carotid ligation; all SHRSP and 80% of SHRSR died in 35 and 32 hours in average after ligation, while all WK survived. The predilection sites of lesions in these SHR were consistent with those observed in SHR after natural death. However, the incidence of lesions in basal ganglia, especially in its anteromedial and anterolateral parts, were markedly increased by the acute induction of lesions in comparison with spontaneous lesions observed in SHRSP at autopsy. These findings confirmed that cerebral lesions were acceleratedly induced by simultaneous bilateral carotid ligation even in young SHRSP and SHRSR, and that these lesions developed at the minor loci of cerebral circulation fed by recurrent branches, especially at the basal ganglia fed by lateral lenticulostriate arteries and Heubner's arteries which branched off with a sharp angle from middle and anterior cerebral arteries, respectively. The preponderant occurrence of the lesions in basal ganglia and the increased incidence of cerebral hemorrhage indicate that the acute induction of the lesions by simultaneous bilateral carotid ligation makes SHRSP and SHRSR better models with very similar lesions to those in man.