Abstract
Transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) can be an efficient way to modulate cortical excitability and promote motor recovery following stroke. However, the effects of M1 tDCS on behavior have been highly variable across individuals. Here we explored whether another motor region that is less often affected by stroke (dorsal premotor cortex, PMd) could also modulate cortical excitability. We also examined motor network neural complexity changes following stimulation of either M1 or PMd using simultaneous fMRI. Forty-six participants took part in a single session during which they received simultaneous tDCS-fMRI over M1 or PMd. tDCS over PMd leads to more reliable changes in both cortical physiology and motor network complexity than M1-tDCS. These results provide new insight into tDCS targets for modulating motor excitability.
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