Abstract
The laboratory rats offer a mammalian system model characterized functionally and serve as standard organism for the analysis of an important number of biomedical features: cardiovascular, metabolic, neurological, neurobehavioral diseases, organ transplantation, autoimmune diseases, cancer, renal diseases, etc.
Highlights
The upper molars in the Wistar rat are in contact with the maxillary sinus and the incisors are essential for food and quality of life [5,7]
During the exodontia procedures performed in this work, groups of 4 rodents were moved to the operating room in individual cages and these showed an attitude of isolation and fear after the surgical procedure was performed on the first experimental animal, possibly because of the above
During the experimental phase of this research work the animals were administered 10 minutes before anesthesia by subcutaneous Atropine Sulfate in doses of 0.1 mg/Kg in order to reduce salivation and prevent bradycardia associated with anesthesia, was used the dose of 50 mg Ketamine/Kg (Heber Biotec®) and 5 mg Xilazine/Kg (Seton®.), Laboratories Calier)) intramuscular in 8 animals producing cardiac arrest in two of them reason why in the remaining 13 animals 40 mg of ketamine/Kg and 5 mg of Xilazine/Kg was applied without presenting mortality allowing the accomplishment of the exodontia of molars and a time of work of 30 minutes approximately, it is probable that this dose was the effective one for being animals of low weight
Summary
The laboratory rats offer a mammalian system model characterized functionally and serve as standard organism for the analysis of an important number of biomedical features: cardiovascular, metabolic, neurological, neurobehavioral diseases, organ transplantation, autoimmune diseases, cancer, renal diseases, etc. During the exodontia procedures performed in this work, groups of 4 rodents were moved to the operating room in individual cages and these showed an attitude of isolation and fear after the surgical procedure was performed on the first experimental animal, possibly because of the above In this sense it is important to take the described forecast. During the experimental phase of this research work the animals were administered 10 minutes before anesthesia by subcutaneous Atropine Sulfate in doses of 0.1 mg/Kg in order to reduce salivation and prevent bradycardia associated with anesthesia, was used the dose of 50 mg Ketamine/Kg (Heber Biotec®) and 5 mg Xilazine/Kg (Seton®.), Laboratories Calier)) intramuscular in 8 animals producing cardiac arrest in two of them reason why in the remaining 13 animals 40 mg of ketamine/Kg and 5 mg of Xilazine/Kg was applied without presenting mortality allowing the accomplishment of the exodontia of molars and a time of work of 30 minutes approximately, it is probable that this dose was the effective one for being animals of low weight.
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