Abstract
In the last years, procalcitonin (PCT) has been proposed as an early marker of infections in newborns having registered different results. In this study, we aimed to investigate the value of serum procalcitonin for the diagnosis of sepsis in neonates and children procalcitonin in the diagnosis of neonatal sepsis and in children up to 1 year in the pathology of therespiratory system, gastrointestinal pathology, etc. At first, we established the clinical and paraclinical signs of systemic inflammation: increasing the temperature of the system, tachycardia, laboratory test: leukocytosis, C-reactive protein - for the diagnosis of sepsis.Some studies show that PCT gave a sensitivity between 83-100% and a specificity between 70-100% in early diagnosis of neonatal sepsis [1-7]; other researches question the accuracy of PCT in detecting neonatal sepsis.Procalcitonin (PCT) has been proposed as a marker of bacterial sepsis in critically ill patients. PCT is a precursor of calcitonin and a 116 amino acids protein. PCT levels more than 0.5 mg/dl are useful to determine the type of infectious process (bacterial or not).
Highlights
In the last years, procalcitonin (PCT) has been proposed as an early marker of infections in newborns having registered different results
More and more studies have been focused on this immune complex identifying and using various biomarkers having great potential for early diagnosis of sepsis and the pathology associated with pregnancy [14-19]
- for normal PCT values, the abdominal percentage was significant greater than the respiratory percentage, which is equivalent to the fact that the percentage of children with pathological PCT values is significantly increased in the case of respiratory pathology compared to the abdominal (p=0.029)
Summary
Procalcitonin (PCT) has been proposed as an early marker of infections in newborns having registered different results. Biomarkers are becoming more and more important in the early diagnosis of infectious disease. More and more studies have been focused on this immune complex identifying and using various biomarkers having great potential for early diagnosis of sepsis and the pathology associated with pregnancy [14-19]. Bacterial endotoxins have a crucial role in the process of inducing this protein; Procalcitonin levels closely correlate with the severity and spread of the infection.
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