Abstract
Introduction: Patients with urinary tract obstruction are often accompanied by urinary tract infections. In some cases, it develops into urosepsis that increases mortality. Early detection capability is essential. The purpose of this study was to determine the role of serum procalcitonin (PCT), nitrite urine (NU) and white blood cell (WBC) as urosepsis predictors in patients with urinary obstruction.
 Methods: This is a cross-sectional study involving 36 samples carried out at our hospital using consecutive sampling technique from December 2016 to February 2017. Statistical analyses used were a bivariate test and multivariate test using Poisson regression.
 Results: From the bivariate test analysis, serum PCT level of ≥0.25 ng/ml, positive result for NU, and a WBC amount of ≥12,000 cells/mm3 were predictors for urosepsis. In the multivariate test, we obtained a PCT serum level of ≥0.25 ng/ml, and WBC of ≥12,000 cells/mm3 were true predictors of urosepsis in patients with urinary tract obstructions with infections.
 Conclusion: Serum PCT and WBC can be used as a predictor of urosepsis in patients with urinary tract obstruction.
Highlights
Patients with urinary tract obstruction are often accompanied by urinary tract infections
This study aims to examine the role of serum PCT, nitrite urine (NU), and white blood cell (WBC) levels as predictors of urosepsis in patients with urinary
From multivariate Poisson regression analysis (Table 3), we found that serum PCT levels (RR: 7.158) and WBC (RR: 3.64) were good predictors of the occurrence of urosepsis in patients with urinary tract obstruction with infection. 28
Summary
Patients with urinary tract obstruction are often accompanied by urinary tract infections. We obtained a PCT serum level of ≥0.25 ng/ml, and WBC of ≥12,000 cells/mm[3] were true predictors of urosepsis in patients with urinary tract obstructions with infections. Most are found in the lower urinary tract, especially men with an incidence of 15 out of 1,000 people per year and experience an increase of 38 out of 1,000 people per year at the age of 75 to 79 years.[1] Out of these, 12% may develop into urosepsis.[2] This situation causes an increase in mortality, which reaches 20-40% in severe urosepsis.[3,4,5,6] Urosepsis caused by urinary tract obstruction is up to 80%.3,4,7.
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