高脂血症患者に対するprobucolの長期使用経験

Abstract

Long-term therapy with probucol (750mg/day) involving 65 cases of hyperlipidemic patients resulted in the following observations:1) Serum total cholesterol was reduced significantly after 1 month of probucol treatment and the reductive effect lasted for the entire 24 month administration period thereafter. The mean reduction rate was from 15.2% to 20.1%. The effect was remarkable in the group whose total cholesterol level at baseline was high.2) No significant reduction was observed in triglyceride, however, the group whose baseline level was over 150mg/dl showed a significant reduction at the 15 month administration.3) HDL-cholesterol was also decreased after treatment of probucol and the group whose baseline level was less than 40mg/dl showed no significant reduction.4) LDL-cholesterol was decreased significantly by probucol therapy at 1 month period and thereafter. The reduced amount varied from 31mg/dl to 43mg/dl in mean and mean reduction rate was 15.0% to 22.1%.5) No significant change was observed in atherogenic index during 24 month administration period.6) In a few cases, increases of serum GOT and GPT levels manifested, but most of them were minor of nature.7) The side effect was diarrhea which was noted in 1 case and the symptom was disapeared by ceasing the therapy.In conclusion, probucol is considered to be a safe and highly beneficial drug in hyperlipidemic patients.