Abstract
In this review methodological problems in the measurement of quality of life in non-ulcer dyspepsia (NUD) patients are discussed. To date very few validated outcome measures are available for NUD-trials. It is unclear whether non GI-related symptoms need to be measured by these instruments in addition to GI-symptoms. Another important issue is how overlap with patients who suffer from gastro-esophageal reflux disease can be avoided.
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