Year-end Sale % OFF 
Abstract
Results of investigations regarding the difficulties of benzylgermanium determination by high performance liquid chromatography using standard octadecyl stationary phases have been substantiated on the molecular level. The analyzed organogermanium compounds are biologically active and some are used in oncology. Investigations showed modifications of the octadecyl stationary phase caused by the above-mentioned derivatives. These modifications have been confirmed by infrared spectroscopy with Fourier transform (FTIR), 13C CP/MAS Nuclear Magnetic Resonance techniques (NMR), 29Si CP/MAS NMR, and scanning microscopy. The strongest bonds are formed by benzyltrichlorogermanium but the tribenzyl derivative with a sterically large group and the long, 18-carbon chains, is bound only weakly. It also interacts to the smallest extent with residual silanols of the octadecyl phase. Mass ratio germanium to silica calculated on the base of scanning display after modification was 12.63% for monobenzyl derivative, 12.49%, for dibenzyl, and 5.6% for tribenzyl.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
