Abstract
The review gives data on shortcomings in the antimicrobial measures that are associated with the defects in the effective treatment of urinary system infections, such as the high risk of disease relapses and the stable proportion of secondary pyelonephritis among the causes of chronic renal failure. The vulnerability of this approach is to accelerate the rate of acquiring the resistance of uropathogens to the currently available antibiotics that may also have a number of side effects, including those involved in the pathogenesis of urinary tract infections. Difficulties in conducting adequate causal therapy are also associated with some subjective factors that largely hamper the personalized diagnosis of diseases of causative agents.
Highlights
The review gives data on shortcomings in the antimicrobial measures that are associated with the defects in the effective treatment of urinary system infections, such as the high risk of disease relapses and the stable proportion of secondary pyelonephritis among the causes of chronic renal failure
The vulnerability of this approach is to accelerate the rate of acquiring the resistance of uropathogens to the currently available antibiotics that may have a number of side effects, including those involved in the pathogenesis of urinary tract infections
Указанные эпидемиологические исследования входят в противоречие с кажущейся простотой проблемы, когда этиология известна, патогенез в определенной мере понятен, диагностика и лечение достаточно разработаны, а актуальность совершенствования медицинского обслуживания пациентов с инфекцией мочевой системы не снижается, что в большой мере следует связать с бытующим упованием на центральное место этиотропной терапии
Summary
Проблемные вопросы этиотропной терапии инфекций мочевыводящих путей у детей уклонно приближается к этому значению – критическому в отношении эффективности применения препарата [12,13,14,15]. Другая группа недостатков этиотропной терапии связана с побочным действием антибиотиков в виде дисбиоза нижних мочевых путей и кишечника.
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