Abstract
Problematic drinking behavior is common in the old and negative consequences of hypoglycemic episodes in type 2 diabetes (T2D) as a result of alcohol consumption have been described previously. Although, associations between such hypoglycemic episodes with reduced muscle mass are discussed, it is uncertain if problematic drinking behavior drives decline of muscle mass and/or muscle function. In the current study, we analyzed data of the Berlin Aging Study II (BASE-II) to examine the association of problematic drinking behavior with muscle mass and grip strength in T2D. Cross-sectional data of 1451 old BASE-II participants (51.6% women; 60–84 years old) were analyzed. Problematic drinking behavior was assessed using the Alcohol Use Identification Test (AUDIT). Muscle mass was measured using dual energy X-ray absorptiometry (DXA), grip strength using a Smedley dynamometer. Adjusted regression models were calculated to assess the association of problematic drinking with muscle mass and grip strength. Problematic drinking was evident in 11.2% of BASE-II participants and in 12.5% of BASE-II participants diabetes was evident. In the fully adjusted model (adjusted for age, trunk fat mass, HbA1c, antidiabetic medication, TSH, CRP, testosterone, physical inactivity, depression (GDS-score), morbidities, smoking status and total energy intake/day, we found a statistically significant association between problematic drinking and muscle mass (β-3.7, SE: 1.3, R2 0.481, partial eta square 0.166, observed power 0.816, p-value 0.005) and grip strength (β-8.1, SE: 3.3, R2 0.222, partial eta square 0.134, observed power 0.670, p-value 0.018) in old diabetic men. These associations were not evident in women and subjects without T2D. Problematic drinking behavior was associated with lower muscle mass and grip strength in old men with diabetes. This topic should be addressed in these subjects as they could be at increased risk for early functional decline, sarcopenia or frailty.
Highlights
IntroductionWww.nature.com/scientificreports autophagy or due to impaired skeletal muscle protein synthesis) and elevation of creatine kinase (CK) have been observed as a consequence of alcohol consumption[10,11]
Berlin, BCRT - Berlin Institute of Health Center for Regenerative Therapies, Berlin, Germany
In the present analysis of BASE-II data we found that problematic drinking behavior was negatively associated with muscle mass (ALM) and muscle function in older men with diabetes
Summary
Www.nature.com/scientificreports autophagy or due to impaired skeletal muscle protein synthesis) and elevation of creatine kinase (CK) have been observed as a consequence of alcohol consumption[10,11]. This is emerging in subjects with type II diabetes (T2D). The aim of the current study on 1451 old participants of the Berlin Aging Study II (BASE-II) was to analyze the association of problematic drinking behavior with muscle mass (appendicular lean mass; ALM) and muscle function (grip strength). The focus of the analysis was not on the assessment of type or amount of alcohol but on unfavorable drinking habits and drinking behavior
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
